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Synlett 1998; 1998(6): 611-612
DOI: 10.1055/s-1998-1726
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N,N-Dibenzyloxycarbonylglycyl Chloride as Useful Ketene Equivalent in the Synthesis of Azetidin-2-ones

Gianfranco Cainelli* , Paola Galletti, Daria Giacomini
  • *Dipartimento di Chimica "G. Ciamician", Via Selmi, 2, I-40126 Bologna (Italy); Fax + (51)25 94 56; E-mail: cainelli@ciam.unibo.it
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Publication History

Publication Date:
31 December 2000 (online)

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N,N-3-Dibenzyloxycarbonylaminoazetidin-2-ones have been conveniently prepared from N,N-dibenzyloxycarbonylglycyl chloride and imines or hexahydrotriazines. The β-lactams thus obtained could be monodeprotected by mild hydrogenolysis with Pd on carbon.

glycyl chloride - 3-amino-azetidin-2-ones - (2S)-lactal - hexahydrotriazines - β-lactams