Download PDF
Synlett 1998; 1998(6): 607-608
DOI: 10.1055/s-1998-1746
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Conformational Control in Proton Sources for Enantioselective Protonation of Samarium Enolate Derived From α-Methoxy-Substituted Ketones

Koichi Mikami* , Makoto Yamaoka, Akihiro Yoshida
  • *Department of Chemical Technology, Tokyo Institute of Technology, Meguro-ku, Tokyo 152, Japan
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

High enantioselectivity is achieved in the asymmetric protonation of samarium enolate, regioselectively generated by SmI2-mediated reduction of 2-methoxy-substituted cyclohexanones using achiral diamine- or pro-atropisomeric 2,2′-biphenol-derived chiral diols as proton sources by virtue of the conformational control.

Samarium enolate - enantioselective protonation - conformational control - achiral diamine - achiral pro-atropisomeric biphenol