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Synlett 1998; 1998(7): 718-720
DOI: 10.1055/s-1998-1764
DOI: 10.1055/s-1998-1764
letter
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Polyphosphate Ester-Mediated Synthesis of Dihydropyrimidines. Improved Conditions for the Biginelli Reaction
Further Information
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/synlett/199807/lookinside/thumbnails/10.1055-s-1998-1764-1.jpg)
Dihydropyrimidines 7 are prepared in high yield by a one-pot condensation of aldehydes, acetoacetates, and ureas using a polyphosphate ester-mediated cyclocondensation reaction. Yields are significantly higher than utilizing classical Biginelli reaction conditions.
Biginelli reaction - dihydropyrimidines - N-acyliminium ions - polyphospate ester - calcium channel modulators