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Synlett 1998; 1998(7): 777-779
DOI: 10.1055/s-1998-1780
DOI: 10.1055/s-1998-1780
letter
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New Reaction Mode of the Horner-Wadsworth-Emmons Reaction for the Preparation of α-Fluoro-α,β-unsaturated Esters
Further Information
Publication History
Publication Date:
31 December 2000 (online)
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Excellent E-selectivity was observed in the Horner-Wadsworth-Emmons (HWE) reactions of ethyl 2-fluoro-2-diethylphosphonoacetate 1 with alkyl aryl ketones 2a-f using Sn(OSO2CF3)2 and N-ethylpiperidine. Mg(II)-promoted HWE reactions of 1 with aldehydes 2h,i afforded α-fluoro-α,β-unsaturated esters 3h,i in a Z-selective manner depending on the reaction temperatures.
Horner-Wadsworth-Emmons reaction - tin - magnesium α-fluoro-α,β-unsaturated ester - alkene