Titanocenes as Electron Transfer Catalysts: Reagent Controlled Catalytic Radical Reactions

Andreas Gansäuer

doi:10.1055/s-1998-1785

Synlett 1998; 1998(8): 801-809
DOI: 10.1055/s-1998-1785

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Titanocenes as Electron Transfer Catalysts: Reagent Controlled Catalytic Radical Reactions

Andreas Gansäuer^*

^*Institut für Organische Chemie, Georg-August-Universität, Tammannstr. 2, D-37077 Göttingen, Germany; Fax + 49-551-39 29 44; E-mail: agansae@gwdg.ge

Abstract

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Novel, catalytic processes for conducting transition metal catalzyed reagent controlled radical reaction have been developed. Aldehydes and epoxides are used as radical precursors. After electron transfer binding of the titanocene catalyst in close proximity to the formed radical center allows control of the ensuing reactions. The catalytically active titanocene complex is regenerated by silylation or protonation and in situ reduction with a readily available, cost efficient stoichiometric reductant.

catalysis - chemoselectivity - diastereoselectivity - radical reaction - regioselectivity

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