Download PDF
Synlett 1998; 1998(8): 861-864
DOI: 10.1055/s-1998-1794
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of Epothilones: Stereoselective Routes to Epothilone B

Dieter Schinzer* , Armin Bauer, Jennifer Schieber
  • *Chemisches Institut der Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, D-39106 Magdeburg, Germany; Fax + 49-391-67-12223; E-mail: Dieter.Schinzer@chemie.uni-magdeburg.de
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

In connection with our studies of the total syntheses of epothilones we report our efforts on the syntheses of epothilone B using a macro-lactonization and a metathesis approach. Key reaction for the solution of the acyclic stereoselection is a stereoselective aldol reaction.

epothilones - natural products - anti-tumor-activity - aldol reaction - macro-lactonization - metathesis