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Synlett 1998; 1998(8): 817-827
DOI: 10.1055/s-1998-1813
new tools in synthesis
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Solid Phase Synthesis

Angus R. Brown* , Pedro H. H. Hermkens, Harry C. J. Ottenheijm, David C. Rees
  • *Scientific Development Group, Organon Laboratoires Ltd., Newhouse, Lanarkshire ML1 5SH, Scotland, UK
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Publication History

Publication Date:
31 December 2000 (online)

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Solid phase synthesis is a rapidly expanding area of synthetic chemistry which has been concerned with the synthesis of diverse collections of "drug-like" molecules for use in the drug discovery process. The aim of this review is to introduce the basic concepts and practices of solid phase synthesis to the synthetic chemist. This includes choice of support, linker, development of the synthetic route, reaction monitoring and basic experimental aspects for carrying out reactions on the solid phase. These points are illustrated with the aid of some recent examples from the literature.

combinatorial chemistry - supports - linkers - equipment