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Synlett 1998; 1998(9): 983-984
DOI: 10.1055/s-1998-1830
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Synthesis of Spiro-2-oxazolines

I. Mušič* , A. Golobič, B. Verček
  • *Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerceva 5, 1000 Ljubljana, Slovenia; Fax 386 1258 220; E-mail: Bojan.Vercek@uni-lj.si
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Publication History

Publication Date:
31 December 2000 (online)

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Several spiro-2-oxazolines were synthesized by treatment of 2-benzoylamino-3-chloropropenoic acid with a series of aromatic and heteroaromatic diamines. Alkylation of these compounds took place on the lactam nitrogen of the 3,4-dihydropyrazin-2(1H)-one part of the spiro systems.

spiro-2-oxazolines - fused 3,4-dihydropyrazin-2(1H)-ones - cyclization - N-alkylation