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Synlett 1998; 1998(10): 1108-1110
DOI: 10.1055/s-1998-1870
DOI: 10.1055/s-1998-1870
letter
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Synthesis of the C7-C17 Segment of Epothilones by a 10-membered Ring Closing Metathesis Reaction
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Publication History
Publication Date:
31 December 2000 (online)
The synthesis of the C7-C17 segment of epothilones employing a ring closing metathesis is described. Our approach utilizes the stereoselective methylation of the 10-membered lactone, generated by ring closing metathesis, for introducing the methyl group at C8 and provides an efficient access to strained epothilone derivatives, as well as to the C7-C17 segment of epothilones.
epothilones - ring closing metathesis reaction