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Synlett 1998; 1998(10): 1108-1110
DOI: 10.1055/s-1998-1870
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Synthesis of the C7-C17 Segment of Epothilones by a 10-membered Ring Closing Metathesis Reaction

Kai Gerlach* , Monika Quitschalle, Markus Kalesse
  • *Institut für Organische Chemie, Universität Hannover, Schneiderberg 1b, 30167 Hannover, Germany; Fax + 49(0)511 762 4643; E-mail: Kalesse@mbox.oci.uni-hannover.de
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Publikationsdatum:
31. Dezember 2000 (online)

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The synthesis of the C7-C17 segment of epothilones employing a ring closing metathesis is described. Our approach utilizes the stereoselective methylation of the 10-membered lactone, generated by ring closing metathesis, for introducing the methyl group at C8 and provides an efficient access to strained epothilone derivatives, as well as to the C7-C17 segment of epothilones.

epothilones - ring closing metathesis reaction