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Synlett 1998; 1998(10): 1081-1082
DOI: 10.1055/s-1998-1895
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Dibutyltin Chloride Hydride Complex as a Novel Reductant for Chemoselective Reductive Amination

Ikuya Shibata* , Toshihiro Suwa, Erika Sugiyama, Akio Baba
  • *Department of Applied Chemistry, Faculty of Engineering, Osaka University, 2-1Yamada-Oka, Suita, Osaka 565-0871, Japan; Fax + 81-6-879-7387; E-mail: baba@ap.chem.eng.osaka-u.ac.jp
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Publication Date:
31 December 2000 (online)

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Imine-selective reducing agent Bu2SNClH-HMPA (1) performed effective reductive amination of carbonyl compounds. Various functionalized amines could be prepared in a one-pot procedure. Noteworthy is that highly chemoselective reactions were achieved with the co-existence of other functionalities such as halogen, carbon-carbon double bond and hydroxyl groups.

reductive amination - tin hydride - high coordination