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Synlett 1998; 1998(12): 1325-1326
DOI: 10.1055/s-1998-1975
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A Simple Synthesis of Phosphonoformamides

Colin G. Ferguson* , Gregory R. J. Thatcher
  • *Dept. of Chemistry, Queen's University, Kingston, Ontario, K7L 3N6, Canada; Fax (613)-545-6669; E-mail: thatcher@chem.Queensu.
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Publication History

Publication Date:
31 December 2000 (online)

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A novel route to C-amides of the antiviral drug Foscarnet via the PFA diester 4 is described. The reaction with amines is facilitated by in situ intramolecular cyclization to form a more reactive intermediate.

Foscarnet - prodrug - phosphonate - peptidomimetic