NiCl2/CrCl2-Mediated Coupling Reaction of Ketones with Alkenyl(or Alkynyl, Aryl) Halides Accomplished in the Presence of a Bipyridyl-Type Ligand

Chinpiao Chen

doi:10.1055/s-1998-1984

Synlett 1998; 1998(12): 1311-1312
DOI: 10.1055/s-1998-1984

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NiCl₂/CrCl₂-Mediated Coupling Reaction of Ketones with Alkenyl(or Alkynyl, Aryl) Halides Accomplished in the Presence of a Bipyridyl-Type Ligand

Chinpiao Chen^*

^*Department of Medical Technology, Tzu Chi College of Medicine and Humanities, Hualien, 970, Taiwan, Republic of China; Fax 886 3 8 57 49 65; E-mail: chinpiao@cc.tcu.edu.tw

Abstract

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In this work, alkenyl halides (or triflates) and alkynyl (or aryl) halides are readily coupled with ketones in tetrahydrofuran in the presence of ligand 1, NiCl₂ and CrCl₂ at room temperature subsequently yielding the corresponding allylic alcohols, propargylic alcohols and benzylic alcohols.

NiCl₂/CrCl₂-mediated - Barbier-like reaction - allylic alcohols - propargylic alcohols - benzylic alcohols

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