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Synthesis 1998; 1998(4): 381-385
DOI: 10.1055/s-1998-2047
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Simple Method for Cleavage of Phosphonic Acid Diesters to Monoesters

Antonín Holý*
  • *Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Praha 6, Czech Republic; E-mail: uochb@uochb.cas.cz
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Publication History

Publication Date:
31 December 2000 (online)

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Phosphonic acid dialkyl or diaryl esters give, on treatment with alkali azide or alkali iodide in DMF at 100 °C, quantitatively and specifically the corresponding monoesters. The reaction is applied in a series of acyclic nucleotide analogs for the preparation of PMEA monoesters and related compounds.

phosphonic acid diester - phosphonic acid monoester - ester cleavage - acyclic nucleotide analogs - antivirals