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DOI: 10.1055/s-1999-13958
Georg Thieme Verlag Stuttgart · New York
Antineoplastic Agents III: Steroidal Glycosides from Solanum nigrum
Publication History
March 17, 1998
June 13, 1998
Publication Date:
31 December 1999 (online)
![](https://www.thieme-connect.de/media/plantamedica/199901/lookinside/thumbnails/10.1055-s-1999-13958-1.jpg)
Abstract:
By bioactivity-guided fractionation, three known steroidal glycosides, β 2-solamargine (1), solamargine ( 2), and degalactotigonin (3), were isolated from Solanum nigrum. Compounds 1 - 3 induced morphological abnormality in Pyricularia oryzae mycelia with MMDC (minimum morphological deformation concentration) values of 63.0, 38.5, and 97.2 μM, respectively. This is the first report on the isolation of 1 from this species and on the cytotoxicity of 1 - 3 on six cultured human solid tumor cell lines HT-29 (colon), HCT-15 (colon), LNCaP (prostate), PC-3 (prostate), T47D (breast), and MDA-MB-231 (breast) in vitro. The cytotoxic assay indicated that 2 is the main antineoplastic agent in S. nigrum. The structures of 1 - 3 were elucidated on the basis of chemical evidence and spectral analysis, especially by 2D-NMR analysis.
Key words:
Solanum nigrum - Solanaceae - steroidal glycosides - antineoplastic agents - cytotoxicity - Pyricularia oryzae