Abstract:
In addition to β-sitosterol and α-amyrin detected in all the investigated
species, the extract of the aerial parts of Artemisia
giraldii var. giraldii gave stigmasterol, daucosterol,
sesamine, luteolin, eupafolin, hispidulin, eupatilin, belamcanidin, pinitol,
artemin, ridentin, and a new antifungal monoterpene (named santolinylol) while
that of the aerial parts of A. mongolica afforded
sesamine, eupafolin, eupatilin, matricarin, and a new germacranolide (3-oxo-11αH-germacra-1(10)E,4
Z-dien-12,6α-olide), and that of the aerial parts of
A. vestita yielded stigmasterol, daucosterol, umbelliferone, scopolin,
scoparone, and isoscopoletin-O-glucoside. Pinitol,
first reisolated from Artemisia genus, was shown
to inhibit the growth of the human pathogenic fungi Candida
albicans, Aspergillus flavus,
A. niger, Geotrichun candidum,
Trichophyton rubrum, and Epidermophyton floccosum . Umbelliferone was also active against Candida tropicalis , A. flavus, G. candidum , T. rubrum, and
E. floccosum. The flavones hispidulin and belamcanidin were almost
equally inhibitory to the growth of A. flavus, G. candidum, T. rubrum , and E. floccosum, and santolinylol
to C. albicans, A. flavus , A. niger, G. candidum , T. rubrum, and
E. floccosum. In addition, ridentin was active against the growth
of the plant pathogenic fungus Cladosporium cucumerinum .
Key words:
Artemisia giraldii var.
giraldii
-
A. mongolica
-
A. vestita
- Compositae - antifungal - sterols - coumarins - flavones - monoterpenes - sesquiterpenes - germacranolides - eudesmanolide - guaianolide - santolinylol - 3-oxo-11αH-germacra-1(10)
E,4Z-diene-12,6α-olide
