Inhibitory Effects of Tetragalloylglucose and Digalloylhamamelose on Adhesion and in vitro Invasion of Mouse Lung Carcinoma Cells

null Kouichi Saeki; Yutaka Shoji; Tadataka Noro; Toshio Miyase; Yoshiyuki Nakamura; Masataka Funayama; Mamoru Isemura

doi:10.1055/s-1999-13985

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Planta Med 1999; 65(3): 227-229
DOI: 10.1055/s-1999-13985

Original Paper

Georg Thieme Verlag Stuttgart · New York

Inhibitory Effects of Tetragalloylglucose and Digalloylhamamelose on Adhesion and in vitro Invasion of Mouse Lung Carcinoma Cells

Kouichi Saeki¹ , Yutaka Shoji¹ , Tadataka Noro² , Toshio Miyase³ , Yoshiyuki Nakamura³ , Masataka Funayama⁴ , Mamoru Isemura¹

¹School of Food and Nutritional Sciences, University -of Shizuoka, Shizuoka, Japan
²Graduate School of Nutritional and Environmental -Sciences, University of Shizuoka, Shizuoka, Ja
³School of Pharmaceutical Sciences, University -of Shizuoka, Shizuoka, Japan
⁴Technical Research Laboratory, Kurabo Industries -Ltd., Neyagawa, Osaka, Japan

Further Information

Publication History

June 2, 1998

September 13, 1998

Publication Date:
31 December 1999 (online)

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Abstract:

Tetragalloylglucose (TgG) and digalloylhamamelose (DgH) were found to inhibit adhesion to and invasion through Matrigel of mouse Lewis lung carcinoma LL2-Lu3 cells, which are highly metastatic. TgG inhibited matrix metalloproteinases (MMPs) from the tumor cells like (-)-epigallocatechin gallate, whereas DgH did not. These results suggest that TgG and DgH inhibit tumor cell invasion by inhibiting MMPs and/or cell adhesion of the tumor cells.

Key words:

Tetragalloylglucose - digalloylhamamelose - hamamelitannin - (-)-epigallocatechin gallate - matrix metalloproteinases - cell adhesion - tumor cell invasion