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Planta Med 1999; 65(3): 250-254
DOI: 10.1055/s-1999-13988
Original Paper

Georg Thieme Verlag Stuttgart · New York

Activity Against Mycobacterium tuberculosis of Alkaloid Constituents of Angostura Bark, Galipea officinalis

P. J. Houghton1 , T. Z. Woldemariam2 , Y. Watanabe1 , M. Yates2
  • 1Pharmacognosy Research Laboratories, Department of Pharmacy, King's College London, London, U.K.
  • 2Public Health Laboratories Service Regional Tuberculosis Centre, Pathology Laboratory, Dulwich Hospital, London, U.K.
Further Information

Publication History

June 12, 1998

November 15, 1998

Publication Date:
31 December 1999 (online)

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Abstract:

The activity of an ethanolic extract of Galipea officinalis bark against Mycobacterium tuberculosis was shown to reside mainly in the basic alkaloidal fraction although the major part of the alkaloids present were in the neutral fraction. Six alkaloids were isolated from the bark including two other alkaloids not previously reported from G. officinalis and a new quinoline named allocuspareine, whose structure was determined by spectroscopic methods. 1H- and 13C-NMR spectral data for three of these compounds are reported for the first time. Isolation and testing of fractions and individual alkaloids against ten strains of M. tuberculosis showed that all the alkaloids possessed some activity but that the unidentified most polar basic fraction exhibited the greatest effect.

Key words:

Galipea officinalis - Rutaceae - allocuspareine - quinoline alkaloids - carbon-13 NMR spectra - anti-tuberculosis activity