Antispasmodic Activity of Thymus vulgaris Extract on the Isolated Guinea-Pig Trachea: Discrimination Between Drug and Ethanol Effects

Adolf Meister; Günther Bernhardt; Volker Christoffel; Armin Buschauer

doi:10.1055/s-1999-14006

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Planta Med 1999; 65(6): 512-516
DOI: 10.1055/s-1999-14006

Original Paper

Georg Thieme Verlag Stuttgart · New York

Antispasmodic Activity of Thymus vulgaris Extract on the Isolated Guinea-Pig Trachea: Discrimination Between Drug and Ethanol Effects

Adolf Meister¹ , Günther Bernhardt¹ , Volker Christoffel² , Armin Buschauer¹

¹ Institut für Pharmazie, Universität Regensburg, Regensburg, Germany
² Plantamed Arzneimittel GmbH, Neumarkt/Opf., Germany

Further Information

Publication History

October 29, 1998

March 14, 1999

Publication Date:
31 December 1999 (online)

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Abstract

The effect of an extract of Thymus vulgaris on induced spasms was investigated on guinea-pig trachea preparations. By the experimental setup used, effects of ethanol as the vehicle could be differentiated from the activity of the herbal constituents. The extract reversibly and concentration-dependently antagonized the contraction of the Musculus transversus tracheae, provoked by four different spasmogens (BaCl₂, carbachol, histamine, prostaglandin F_2α). The degree of the antispasmodic activity was dependent on the individual spasmogen with prostaglandin F_2α being most efficiently antagonized.

Key words:

Thymus vulgaris - Lamiaceae - guinea-pig trachea - antispasmodic activity - ethanol