Abstract
The effect of an extract of Thymus vulgaris on
induced spasms was investigated on guinea-pig trachea preparations. By the
experimental setup used, effects of ethanol as the vehicle could be differentiated
from the activity of the herbal constituents. The extract reversibly and concentration-dependently
antagonized the contraction of the Musculus transversus
tracheae, provoked by four different spasmogens (BaCl2, carbachol,
histamine, prostaglandin F2α). The degree of the antispasmodic
activity was dependent on the individual spasmogen with prostaglandin F
2α being most efficiently antagonized.
Key words:
Thymus vulgaris
- Lamiaceae - guinea-pig trachea - antispasmodic activity - ethanol
