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DOI: 10.1055/s-1999-14026
Georg Thieme Verlag Stuttgart · New York
Lignan and Phenylpropanoid Glycosides from Lancea tibetica and Their Antitumor Activity
Publikationsverlauf
November 20, 1998
April 6, 1999
Publikationsdatum:
31. Dezember 1999 (online)
![](https://www.thieme-connect.de/media/plantamedica/199906/lookinside/thumbnails/10.1055-s-1999-14026-1.jpg)
Abstract
A new lignan glucoside, the first 7,9′-monoepoxytetrahydrofuran type lignan with the cis-relationship of H-7 and H-8, named tibeticoside (1), as well as ten known compounds have been isolated from the medicinal plant (roots, stems and leaves) Lancea tibetica. The structure of tibeticoside ( 1) has been elucidated on the basis of chemical and spectral evidence, especially by 2D-NMR (1H-1H COSY, HMQC, HMBC, NOESY). In addition, sylvatesmin (6) exhibited effective antitumor activity on B16 cells.
Key words:
Lancea tibetica - Scrophulariaceae - lignan glucoside - phenylpropanoid glycosides - tibeticoside - antitumor activity