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Planta Med 1999; 65(7): 604-609
DOI: 10.1055/s-1999-14032
Original Paper

Georg Thieme Verlag Stuttgart · New York

Antiviral and Anticoagulant Activities of a Water-Soluble Fraction of the Marine Diatom Haslea ostrearia

J.-P. Bergé1 , N. Bourgougnon2 , S. Alban3 , F. Pojer2 , S. Billaudel4 , J.-C. Chermann5 , J. M. Robert6 , G. Franz3
  • 1 Laboratoire de Biochimie et molécules Marines, IFREMER, rue de l'Ile d'Yeu, Nantes, France
  • 2 Laboratoire de Biologie et Biochimie marines (LBBM), Université de La Rochelle, La Rochelle, France
  • 3 Pharmazeutische Biologie, Universität Regensburg, Regensburg, Germany
  • 4 Unité fonctionelle de Virologie, Institut de Biologie, CHRU de Nantes, Nantes, France
  • 5 INSERM U322, Unité de Recherche sur les Rétrovirus et Maladies associées, Marseille, France
  • 6 Laboratoire de Biologie Marine, ISOMer (Institut des Substances et Organismes de la Mer), Université de Nantes, Nantes, France
Further Information

Publication History

December 2, 1998

March 20, 1999

Publication Date:
31 December 1999 (online)

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Abstract:

A water-soluble fraction from the marine diatom Haslea ostrearia was capable to inhibit the in vitro replication of HSV-1 in Vero cells with 50 % inhibitory concentration (EC50) of 14 μg/ml at a multiplicity of infection of 0.01 ID50/cells. In addition, this fraction delayed the HIV-1-induced syncitia formation on MT4 cells. At concentrations up to 200 μg/ml, no cytotoxicity was observed for both the Vero and MT4 cells. The fraction only inhibited the blood coagulation process at concentrations considerably exceeding the EC50.

Key words:

Diatom, Haslea ostrearia - Naviculaceae - pennate, anti-HSV-1 activity - anti-HIV-1 activity - anticoagulant activity