Planta Medica, Inhaltsverzeichnis Planta Med 1999; 65(8): 687-689DOI: 10.1055/s-1999-14042 Original Paper Georg Thieme Verlag Stuttgart · New York Anti-Tumour Activity of Two 19-Nor-clerodane Diterpenes, trans-Dehydrocrotonin and trans-Crotonin, from Croton cajucara Noema F. Grynberg1 , Aurea Echevarria1 , Juliana E. Lima2 , Sônia S. R. Pamplona3 , Angelo C. Pinto4 , Maria Aparecida M. Maciel4 1 Departamento de Química, Universidade Federal Rural do Rio de Janeiro, Rio de Janeiro, Brazil 2 Departamento de Farmacologia e Psicobiologia, Universidade Estadual do Rio de Janeiro, Brazil 3 Departamento de Química, Universidade Federal do Pará, Brazil 4 Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil Artikel empfehlen Abstract als PDF herunterladen Artikel einzeln kaufen Abstract The effects of two nor-diterpenes, trans-dehydrocrotonin (DCTN) and trans-crotonin (CTN) from Croton cajucara (Euphorbiaceae), on the survival of mice bearing Sarcoma 180 and Ehrlich carcinoma ascitic tumours, on the proliferation of cultured Ehrlich cells and TNFα activity were determined. When the mice were treated with 80 and 120 mg/kg of DCTN or 38 mg/kg of 5-FU a significant anti-tumour activity was obtained (%T/C of 128 - 140). The cytotoxicity against Ehrlich carcinoma was 16 μM for DCTN and CTN whereas the flavonoid quercetin was cytotoxic at 44 μM in 48 h cell culture. No apoptosis was seen on in vitro electrophoresis of DNA extracted from the tumour cells treated with DCTN and CTN. A significant TNFα activity was detected in Ehrlich tumour-bearing mice treated with DCTN suggesting an enhanced immune function. Key words Croton cajucara - Euphorbiaceae - clerodane diterpene - anti-tumour activity - TNFα activity PDF (221 kb)
