Planta Med 1999; 65(8): 740-743
DOI: 10.1055/s-1999-14054
Original Paper

Georg Thieme Verlag Stuttgart · New York

New Triterpenoids with Antibacterial Activity from Zizyphus joazeiro

Wolfgang Schühly1 , Jörg Heilmann1 , Ihsan Çalis2 , Otto Sticher1
  • 1 Department of Pharmacy, Swiss Federal Institute of Technology (ETH) Zurich, Zürich, Switzerland
  • 2 Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
Further Information

Publication History

February 10, 1999

May 22, 1999

Publication Date:
31 December 1999 (online)

Abstract

The stem bark of the Brazilian medicinal plant Zizyphus joazeiro C. Mart. was phytochemically investigated. Three known compounds (betulinic, ursolic and alphitolic acid) and three new derivatives of betulinic acid, 7β-(4-hydroxybenzoyloxy)-betulinic acid, 7β-(4-hydroxy-3′-methoxybenzoyloxy)-betulinic acid and 27-(4-hydroxy-3′-methoxybenzoyloxy)-betulinic acid which showed a considerable activity against Gram-positive bacteria were isolated from the dichloromethane extract. The structures were established on the basis of NMR spectroscopy and mass spectrometry.