Biological and Chemical Characterization of the Fraction with Antiherpetic Activity from Achyrocline flaccida

Gabriel García; Lucia Cavallaro; Adriana Broussalis; Graciela Ferraro; Virginia Martino; Rodolfo Campos

doi:10.1055/s-1999-14061

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Planta Med 1999; 65(4): 343-346
DOI: 10.1055/s-1999-14061

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Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Biological and Chemical Characterization of the Fraction with Antiherpetic Activity from Achyrocline flaccida

Gabriel García¹ , Lucia Cavallaro¹ , Adriana Broussalis² , Graciela Ferraro² , Virginia Martino² , Rodolfo Campos¹

¹Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
²Cátedra de Farmacognosia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina

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Publication History

1998

1999

Publication Date:
04 January 2007 (online)

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Abstract

The in vitro antiviral activity demonstrated by aqueous extract (AE) of Achyrocline flaccida on herpes simplex virus type-1 is exerted early during the viral replication, essentially during the viral adsorption to host cells. A bioguided purification process of the AE indicated that negatively charged polysaccharides were responsible for this antiviral activity.

Key words

Antiherpetic activity - antiviral activity - aqueous extract - herpes simplex - Achyrocline flaccida - Compositae - anionic polysaccharides