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DOI: 10.1055/s-1999-14085
© Georg Thieme Verlag Stuttgart · New York
Prevention by a Silymarin/Phospholipid Compound of Ethanol-Induced Social Learning Deficits in Rats
Publikationsverlauf
1998
1999
Publikationsdatum:
04. Januar 2007 (online)

Abstract
We explored the possibility that silymarin (SY), a fraction from Silybum marianum, might protect against the effects of in utero exposure to ethanol upon subsequent social memory function. Three groups of 8 pregnant female Sprague-Dawley rats each were provided with a liquid diet containing 35% ethanol derived calories (EDC). One experimental group received a daily subcutaneous injection of 400 mg/kg SY, the second, a 400 mg/kg oral dose of SY, a third group was maintained on the 35% EDC diet. A fourth group served as the pair-fed control group. The liquid diet regimen was maintained throughout pregnancy. Rats pups were fostered by dams in a fifth group that had been maintained on rat chow. At 90 days the pups were tested for social memory. Social recognition scores recorded for the ethanol pups were significantly poorer than those observed in both SY/ethanol groups and the chow group.
Key words
Fetal alcohol syndrome - silymarin - social recognition - Silybum marianum - Asteraceae