New Tetrahydroprotoberberine N-Oxide Alkaloids and Cytotoxic Constituents of Corydalis tashiroi

Jih-Jung Chen; Chang-Yih Duh; Ih-Sheng Chen

doi:10.1055/s-1999-14090

Planta Medica, Table of Contents

Planta Med 1999; 65(7): 643-647
DOI: 10.1055/s-1999-14090

Original Paper

Georg Thieme Verlag Stuttgart · New York

New Tetrahydroprotoberberine N-Oxide Alkaloids and Cytotoxic Constituents of Corydalis tashiroi

Jih-Jung Chen¹ , Chang-Yih Duh² , Ih-Sheng Chen³

¹ Department of Pharmacy, Tajen Junior College of Pharmacy, Pingtung, Taiwan, Republic of China
² Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China
³ Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Kaohsiung, Taiwan, Republic of China

Abstract

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Abstract

Three new tetrahydroprotoberberine N-oxide alkaloids, (-)-cis-corydalmine N-oxide (1), (-)-trans-corydalmine N-oxide (2), and (-)-trans-isocorypalmine N-oxide (3), along with three known benzo[ c]phenanthridine alkaloids, norsanguinarine (4), dihydrosanguinarine (5), and oxysanguinarine ( 6), six known berberine alkaloids, (-)-tetrahydropalmatine (7), (-)-corydalmine (8), (-)-scoulerine (9), (-)-corynoxidine (10), (-)-epicorynoxidine (11), palmatine ( 12), and protopine (13), have been isolated from the herb Corydalis tashiroi. The structures of these compounds were elucidated by spectroscopic analysis. Three of the isolated compounds show significant cytotoxic activities (ED₅₀ values < 4 μg/ml) against P-388, KB16, A549, and HT-29 cell lines.

Key words:

Corydalis tashiroi - Fumariaceae - alkaloids - berberine - tetrahydroprotoberberine N-oxide (-)-cis-corydalmine N-oxide - (-)-trans-corydalmine N-oxide - (-)-trans-isocorypalmine N-oxide - cytotoxic activity

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