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Planta Med 1999; 65(8): 709-711
DOI: 10.1055/s-1999-14093
Original Paper

Georg Thieme Verlag Stuttgart · New York

Inhibition of Low Density Lipoprotein Oxidation by Tetrahydrofurofuran Lignans from Forsythia suspensa and Magnolia coco

Chien-Chih Chen1 , Hon-Yi Chen2 , Ming-Shi Shiao3 , Yun-Lian Lin1 , Yueh-Hsiung Kuo4 , Jun-Chih Ou1
  • 1 National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China
  • 2 Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China
  • 3 Department of Medical Research and Education, Veterans General Hospital, Taipei, Taiwan, Republic of China
  • 4 Department of Chemistry, National Taiwan University, Taipei, Taiwan, Republic of China
Further Information

Publication History

January 12, 1999

May 22, 1999

Publication Date:
31 December 1999 (online)

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Abstract

Based on the inhibition of Cu2+-induced LDL oxidation as marker, the major antioxidants in the fruits of Forsythia suspensa and the stems of Magnolia coco were identified. Of these bioactive tetrahydrofurofuran lignans, pinoresinol, phillygenin, and syringaresinol were more potent than probucol. Sesamin and fargesin, which do not contain phenol groups, were found much less active.

Key words

Forsythia suspensa (Thunb.) Vahl. - Oleaceae - Magnolia coco (Lour.) DC. - Magnoliaceae - antioxidants - pinoresinol - phillygenin - syringaresinol