Download PDF
Synlett 1999; 1999(3): 339-341
DOI: 10.1055/s-1999-2602
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Efficient Simultaneous Closure of Polysubstituted 1-Aminopyrrole Rings Spaced by a Variable Number of Methylene Groups

Orazio A. Attanasi* , Lucia De Crescentini, Paolino Filippone, Francesca R. Perrulli, Stefania Santeusanio
  • *Istituto di Chimica Organica della Facoltà di Scienze, Università di Urbino, Piazza della Republica 13, 61029 Urbino, Italy; Fax +39 (07 22) 29 07; E-mail: attanasi@fis.uniurb.it
Further Information

Publication History

Publication Date:
31 December 1999 (online)

  PDF Download  Permissions and Reprints All articles of this category

The treatment of alkyl 2-chloroacetoacetate with carbohydrazide, succinic or adipic dihydrazide produces the relevant α,α′-dichlorobishydrazones. In the presence of sodium carbonate, these compounds react at room temperature with β-diketones, β-ketoesters or β-ketoamides to give rise to functionalized 1-carbonyl-aminopyrrole rings spaced by a variable number of methylene groups.

1-aminopyrroles - acyl dihydrazides - 2-chloro-1,3-ketoesters - α,α′-dichlorobishydrazones