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Synlett 1999; 1999(4): 450-452
DOI: 10.1055/s-1999-2647
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Pyrrolidine-Catalyzed Homo-Aldol Condensation Reactions of Aldehydes

Teruhiko Ishikawa* , Eiji Uedo, Siho Okada, Seiki Saito
  • *Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Tsushima, Okayama 700-8530, Japan; Fax 81-86-2 51-82 09; E-mail: seisaito@biotech.okayama-u.ac.jp
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Publication Date:
31 December 1999 (online)

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The first example of synthetically useful pyrrolidine-catalyzed homocoupling reaction of aliphatic aldehydes accelerated by benzoic acid is presented together with a plausible reaction mechanism.

homo-aldol condensation - α,β-unsaturated aldehyde - pyrrolidine catalysis - reverse Michael addition