Download PDF
Synlett 1999; 1999(6): 729-730
DOI: 10.1055/s-1999-2731
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Efficient Synthesis of Aromatic sec-Amides from Esters: Synthetic Utility of Bislithium Amides

Takashi Ooi* , Eiji Tayama, Masao Yamada, Keiji Maruoka
  • *Department of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan; Fax +81 (11) 7 46 25 57; E-mail: maruoka@sci.hokudai.ac.jp
Further Information

Publication History

Publication Date:
31 December 1999 (online)

  PDF Download  Permissions and Reprints All articles of this category

Convenient, efficient preparation of aromatic sec-amides from esters has been accomplished using dilithium amides which are easily prepared by treatment of aromatic amines with 2 equiv of BuLi in THF. This new method allows a facile formation of amide bond even with sterically hindered esters.

aminolysis - esters - aromatic amines - dilithium amides - aromatic sec-amides