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Synlett 1999; 1999(6): 723-724
DOI: 10.1055/s-1999-2733
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Total Syntheses of Trichodenones A-C

Yoshihide Usami* , Atsushi Numata
  • *Osaka University of Pharmaceutical Sciences, Nasahara, Takatsuki, Osaka 569-1094, Japan; Fax +81-7 26-90-10 80; E-mail: numata@oysun01.oups.ac.jp
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Publication History

Publication Date:
31 December 1999 (online)

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Both enantiomers or trichodenones A, and B and C, the cytotoxic metabolites from a strain of Trichoderma harzianum from the sponge Halichondria okadai, have been synthesized from (R)- and (S)-4-hydroxy-2-cyclopentenones as chiral building blocks, respectively. These syntheses allowed assignment of absolute stereostructures for these natural products.

natural products - stereoselective synthesis