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Synlett 1999; 1999(9): 1450-1452
DOI: 10.1055/s-1999-2845
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First Synthesis of Isothianinhydrin, the Second Thiophene Isostere of Ninhydrin

Lan Pham Khanh* , Patrick Dallemagne, Sylvain Rault
  • *Centre d'Etudes et de Recherche sur le Médicament de Normandie, UFR des Sciences Pharmaceutiques, Université de Caen, 1, rue Vaubénard, 14032 Caen cedex, France; Fax + 33(2)31 93 11 88; E-mail: dallemagne@pharmacie.unicaen.fr
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Publication History

Publication Date:
31 December 1999 (online)

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The first synthesis of isothianinhydrin (5,5-dihydroxy-5,6-dihydro-4H-cyclopenta[c]thiophene-4,6-dione), a thiophene isostere of ninhydrin, and of its bromo and chloro derivatives, is reported, as well as a preliminary evaluation of their interest in fingerprint detection area.

isothianinhydrin - ninhydrin - thianinhydrin - cyclopenta[c]thiophene - fingerprints