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Synlett 1999; 1999(10): 1633-1635
DOI: 10.1055/s-1999-2899
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Preparation of New Phosphine Oxide Synthons: Synthesis of an Analogue of Muscarinic Antagonists

Roger G. Hall* , Peter Riebli
  • *Novartis Crop Protection AG, Basel, Switzerland; E-mail: roger_graham.hall@cp.novartis.com
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Publication History

Publication Date:
31 December 1999 (online)

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Protected primary phosphine oxides may be obtained by reaction of ethyl (diethoxyalkyl)phosphinates with organometallic reagents. These products, stable to chromatography or distillation, may be further elaborated into new, functional unsymmetrical secondary and tertiary phosphine oxides. A close analogue of muscarinic antagonists has been prepared using this methodology.

functional phosphine oxides - synthons - muscarinic antagonists