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Synlett 1999; 1999(10): 1563-1566
DOI: 10.1055/s-1999-2916
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Asymmetric Allylic Alkylation Using a Palladium Complex of Chiral 2-(Phosphinoaryl)pyridine Ligands

Katsuji Ito* , Risa Kashiwagi, Kazunori Iwasaki, Tsutomu Katsuki
  • *Department of Chemistry, Fukuoka University of Education, Akama, Munakata, Fukuoka 811-4192, Japan; Fax + 81-92-6 42-26 07
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Publikationsdatum:
31. Dezember 1999 (online)

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A palladium complex of newly designed chiral 2-(phosphinoaryl)pyridine (4b) was found to be an effective catalyst for asymmetric allylic alkylation. High enantioselectivity was achieved in the reactions of both 1,3-diphenyl-2-propen-1-yl acetate (98% ee) and (2E)-1-methyl-2-butenyl phenyl carbonate (93% ee) with dimethyl malonate.

asymmetric allylic alkylations - asymmetric catalysis - palladium - chiral P,N-ligands