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Synlett 1999; 1999(10): 1636-1638
DOI: 10.1055/s-1999-2918
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Highly Efficient Conversion of Benzoates to Alcohols with Sodium Borohydride in DME-MeOH

Atsuhiko Zanka* , Hiroki Ohmori, Takumi Okamoto
  • *Technological Development Laboratories, Fujisawa Pharmaceutical Co. Ltd., 2-1-6 Kashima, Yodogawa-ku, Osaka, 532-8514, Japan; Fax +81 6 63 90 11 83; E-mail: atsuhiko_zanka@po-fujisawa.co.jp
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Publication Date:
31 December 1999 (online)

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Methoxybenzoates were quantitatively reduced to the corresponding alcohols with sodium borohydride in a mixed solvent (DME-MeOH). The described method was applicable to a large scale synthesis.

sodium borohydride - ester - benzoate - alcohol - reduction