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Synlett 1999; 1999(S1): 869-872
DOI: 10.1055/s-1999-3084
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Introduction of 5-Formyl-2′-deoxyuridine into a κB Site: Critical Discrimination of a Base Structure in the Major Groove by NFκB p50 Homodimer

Atsushi Kittaka* , Chikafumi Horii, Tetsuya Kuze, Takashi Asakura, Katsutoshi Ito, Kazuo T. Nakamura, Tadashi Miyasaka, Jun-ichiro Inoue
  • *School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan; Fax +81(3)37 84-82 52; E-mail: akittaka@pharm.showa-u.ac.jp
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Publication Date:
31 December 1999 (online)

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Four kinds of oligonucleotide 26-mers including 5-formyl-2′-deoxyuridine in place of thymidine at the κB site were synthesized. One of the oligonucleotide 26-mers was critically discriminated by the NFκB p50 homodimer in binding.

oligonucleotides - NFκB - κB site - DNA-protein interaction