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Synlett 1999; 1999(S1): 978-980
DOI: 10.1055/s-1999-3107
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Synthesis of an RNA-Peptide Conjugate by Orthogonal Ligation

Michael McPherson* , Martin C. Wright, Peter A. Lohse
  • *Phylos, Inc., 128 Spring Street, Lexington, MA 02421, USA; Fax +1(7 81)4 02 88 00; E-mail: plohse@phylos.com
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Publication History

Publication Date:
31 December 1999 (online)

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A convergent strategy for the synthesis of an RNA-peptide conjugate is presented. Regioselective ligation between a 5′-modified RNA harboring a 5′-thioester group and a peptide carrying an N-terminal cysteine afforded an RNA-peptide conjugate under physiological conditions without the need for protecting groups.

encoded peptide library - RNA-peptide conjugate - orthogonal ligation - nucleic acid-protein conjugate