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Synlett 1999; 1999(S1): 991-993
DOI: 10.1055/s-1999-3114
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The "Triamino-analogue" of Methyl Cholate; A Practical, Large-Scale Synthesis

Anthony P. Davis* , M. Nieves Pérez-Payán
  • *Department of Chemistry, Trinity College, Dublin 2, Ireland; Fax +3 53(1)6 71 28 26; E-mail: adavis@tcd.ie
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Publication Date:
31 December 1999 (online)

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The triamino steroids 2 are in demand as facial amphiphiles and starting materials for supramolecular chemistry. 2 (R = Me) is now available from cholic acid 1 in substantial quantities via a new, high-yielding procedure.

bile acids - scaffold - supramolecular chemistry - facial amphiphile - oxime reduction