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Synlett 1999; 1999(10): 1571-1572
DOI: 10.1055/s-1999-3169
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N-Trityl-Aziridinyl(diphenyl)methanol as an Effective Catalyst in the Enantioselective Addition of Diethylzinc to Aldehydes

Corrine F. Lawrence* , Sandip K. Nayak, Lambertus Thijs, Binne Zwanenburg
  • *Department of Organic Chemistry, NSR Institute for Molecular Structure, Design and Synthesis, University of Nijmegen, Toernooiveld, 6525 ED Nijmegen, The Netherlands; Fax + 31-24-3 65 33 93; E-mail: zwanenb@sci.kun.nl
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Publikationsdatum:
31. Dezember 1999 (online)

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High levels of enantioselectivity have been achieved in the diethylzinc addition to both aromatic and aliphatic aldehydes, employing N-trityl-aziridinyl(diphenyl)methanol as the chiral catalyst. The R- and S-antipodes of the catalyst can readily be prepared from d- and l-serine, respectively.

aziridinylmethanol - catalysis - enantioselective - dialkylzinc and aldehyde