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Synthesis 1999; 1999(2): 306-311
DOI: 10.1055/s-1999-3379
DOI: 10.1055/s-1999-3379
paper
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General Synthetic Method for Naphthyridines and Their N-Oxides Containing Isoquinolinic Nitrogen
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Publikationsverlauf
Publikationsdatum:
31. Dezember 1999 (online)
![](https://www.thieme-connect.de/media/synthesis/199902/lookinside/thumbnails/10.1055-s-1999-3379-1.jpg)
Substituted naphthyridines containing isoquinolinic nitrogen were synthesized by the reaction of o-ethynylpyridinecarbaldehydes with ammonia. The synthesis of their N-oxides was also achieved by a basic cyclization reaction of the same pyridine derivatives via the corresponding oximes.
naphthyridines - N-oxides - cyclization - palladium-catalyzed acetylene cross-coupling - lithiation