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Synthesis 1999; 1999(2): 306-311
DOI: 10.1055/s-1999-3379
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General Synthetic Method for Naphthyridines and Their N-Oxides Containing Isoquinolinic Nitrogen

Atsushi Numata* , Yoshinori Kondo, Takao Sakamoto
  • *Faculty of Pharmaceutical Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai 980-8578, Japan; Fax +81(2 22)17 68 64; E-mail: sakamoto@mail.pharm.tohoku.ac.jp
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Publication Date:
31 December 1999 (online)

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Substituted naphthyridines containing isoquinolinic nitrogen were synthesized by the reaction of o-ethynylpyridinecarbaldehydes with ammonia. The synthesis of their N-oxides was also achieved by a basic cyclization reaction of the same pyridine derivatives via the corresponding oximes.

naphthyridines - N-oxides - cyclization - palladium-catalyzed acetylene cross-coupling - lithiation