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Synthesis 1999; 1999(2): 312-316
DOI: 10.1055/s-1999-3387
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Neopentyl and Neophyl Groups: New Nontransferable Groups for Organocopper and Organozinc Chemistry

Christian Lutz* , Philip Jones, Paul Knochel
  • *Fachbereich Chemie der Philipps-Universität Marburg, Hans-Meerwein-Straße, 35032 Marburg, Germany; Fax +49(64 21)28 21 89; E-mail: Knochel@ps1515.chemie.uni-marburg.de
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Publication Date:
31 December 1999 (online)

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Neopentyl and Neophyl groups have been found to be excellent nontransferable groups for organozinc and organocopper chemistry. We have shown that mixed diorganozincs of the type FG-R-Zn(CH2CMe2R) can be used advantageously for the enantioselective addition to aldehydes. These mixed copper or zinc reagents are also found to be very efficient in the Michael addition to various activated alkenes.

mixed zinc reagents - asymmetric synthesis - conjugate addition - organocuprates - nontransferable groups