Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000084.xml
Synthesis 1999; 1999(5): 811-814
DOI: 10.1055/s-1999-3479
DOI: 10.1055/s-1999-3479
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
An Efficient Synthesis of New 2-Pyronyl-1,5-Benzodiazepine Derivatives
Further Information
Publication History
Publication Date:
31 December 1999 (online)
A series of 3,4-dihydro-2-pyronyl-1,5-benzodiazepines 4 was prepared by the reaction of DHA (dehydroacetic acid), o-PDA (orthophenylenediamine) and aromatic aldehydes in the presence of a catalytic amount of TFA (trifluoroacetic acid). 2-Pyronyl-1,5-benzodiazepines 6 in turn were synthesised from DHA, o-PDA and acetal [dimethyl formamide-dimethyl acetal (DMF-DMA) or dimethyl acetamide-dimethyl acetal (DMA-DMA)] under basic catalysis.
dehydroacetic acid - orthophenylenediamine - aromatic aldehydes - acetal - pyronyl side chain - 1,5-benzodiazepines