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Synthesis 1999; 1999(5): 757-759
DOI: 10.1055/s-1999-3480
short paper
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The Ready Conversion of 2,5-Disubstituted Furans into Isothiazoles

Sean M. Laaman* , Otto Meth-Cohn, Charles W. Rees
  • *Chemistry Department, University of Sunderland, Sunderland, SR1 3SD, UK; E-mail: otto.meth-cohn@sunderland.ac.uk
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Publication Date:
31 December 1999 (online)

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Various 2,5-disubstituted furans are very readily and efficiently transformed into 5-acyl-3-substituted isothiazoles by the action of ethyl carbamate, thionyl chloride and pyridine.

furans - isothiazoles - thiazyl chloride - trithiazyl trichloride - ethyl carbamate - thionyl chloride