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Synthesis 1999; 1999(1): 55-57
DOI: 10.1055/s-1999-3667
short paper
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A Convenient Trifluoroacetylation Reagent: N-(Trifluoroacetyl)succinimide

Alan R. Katritzky* , Baozhen Yang, Guofang Qiu, Zhongxing Zhang
  • *Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA; Fax +1(352)3 92 91 99; E-mail: Katritzky@chem.ufl.edu
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Publication History

Publication Date:
31 December 1999 (online)

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N-(Trifluoracetyl)succinimide, easily prepared from trifluoroacetic anhydride and succinimide forms a novel, convenient trifluoracetylating reagent. It trifluoroacetylates alcohols, phenols and amines, to generate trifluoroacetate esters, and trifluoracetamides in excellent yields with very efficient work up procedures.

N-(trifluoroacetyl)succinimide - trifluoroacetylating reagent - trifluoroacetate esters - trifluoroacetamides

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