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Synthesis 1999; 1999(1): 162-165
DOI: 10.1055/s-1999-3674
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A Simple Method for the Synthesis of N β-Glycosylated-Asparagine and -Glutamine Derivatives

Mamoru Mizuno* , Ikuyo Muramoto, Katsuaki Kobayashi, Hiroshi Yaginuma, Toshiyuki Inazu
  • *The Noguchi Institute, 1-8-1, Kaga, Itabashi-ku, Tokyo 173-0003, Japan; Fax +81(3)39 64 40 71; E-mail: LDI02534@nifty.ne.jp
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Publication Date:
31 December 1999 (online)

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N β-Glycosylated-asparagine and -glutamine derivatives, which are useful precursors for the synthesis of N-glucopeptides and their analogs, were obtained in good yields by the reaction of a glycosyl azide and an N α-protected-aspartic/glutamic acid α-monoester in the presence of trialkylphosphine at low temperature.

glycopeptide - glycosylasparagine - glycosylglutamine - phosphine - glycosyl azide