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Synthesis 1999; 1999(1): 51-54
DOI: 10.1055/s-1999-3675
short paper
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A One-Step Approach to 1-(Fluoroalkyl)indolizine Derivatives

Xue-chun Zhang* , Wei-yuan Huang
  • *Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China; Fax +86(21)64 16 61 28; E-mail: wyhuang@pub.sioc.ac.cn
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Publication Date:
31 December 1999 (online)

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A facile one-step method is presented for the synthesis of 1-(fluoroalkyl)-substituted indolizine derivatives in moderate to good yields by reactions of pyridinium, 4-methylpyridinium, isoquinolinium, and pyridazinium ylides with 2-bromo-3,3,3-trifluoropropene and 1-iodo-2-(polyfluoroalkyl)ethenes, respectively, in the presence of base.

1-(fluoroalkyl)indolizines - heteroaromatic N-ylides - 1,3-dipolar addition