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Synthesis 1999; 1999(1): 152-156
DOI: 10.1055/s-1999-3682
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New Conformationally Restricted Phosphorus- and Sulfur-Containing Structure Mimetics of Glutamic Acid - Pro-Glu Chimeras

Hartmut Schedel* , Joachim Sieler, Lothar Hennig, Klaus Burger
  • *University of Leipzig, Department of Organic Chemistry, Talstr. 35, D-04103 Leipzig, Germany; Fax +49(3 41)9 73 65 99; E-mail: burger@organik.orgchem.uni-leipzig.de
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Publication Date:
31 December 1999 (online)

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The synthesis of several analogues of glutamic acid via regio- and stereoselective 1,3-dipolar cycloaddition reactions from N-chloromethylated hexafluoroacetone-protected α-amino acids is described.

amino acids - glutamic acid - chimeras - proline - [3 + 2] cycloaddition - hexafluroacetone