Download PDF
Synthesis 1999; 1999(1): 64-65
DOI: 10.1055/s-1999-3695
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Practical Method for the Preparation of Nitriles from Primary Amides Under Non-Acidic Conditions

D. Subhas Bose* , B. Jayalakshmi
  • *Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad 500 007, India; Fax +91-40-7 17 33 87/7 17 37 57; E-mail: root@csiict.ren.nic.in
Further Information

Publication History

Publication Date:
31 December 1999 (online)

  PDF Download  Permissions and Reprints All articles of this category

In order to establish a mild conversion method of primary amides to nitriles, various types of carboxamides were treated with trifluoromethanesulfonic anhydride and triethylamine, as a dehydrating agent to obtain the desired nitriles in 84-95% yields.

trifluoromethanesulfonic anhydride - carboxamides - dehydration