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Synlett 1999; 1999(10): 1606-1608
DOI: 10.1055/s-1999-823029
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The Application of the Pmc-Protecting Group to Reduced Peptide Bond Synthesis

Aleksandra S. Kołodziejczyk, Ewa Sugajska, Bogdan Falkiewicz, Kazimierz Wiśniewski
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Publication Date:
31 December 1999 (online)

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Pseudodipeptides of the Glyψ(CH2NH)Aaa type were synthesized in the Mitsunobu reaction of Boc-aminoalcohols with Pmc-protected aminoesters. The usefulness of the synthesis and its compatibility with SPPS were proved.

alkylations - amino alcohols - Mitsunobu reaction - peptides - solid-phase synthesis